Matlock Jeffries, MD

University of Oklahoma Health Sciences Center

Dr. Matlock Jeffries is a physician scientist and clinical rheumatologist with a research interest in epigenetic, transcriptomic, and microbiotic contributions to osteoarthritis development and the clinical application of epigenetic modifications both as biomarkers of OA and as a potential treatment for OA.  His research focuses on changes in epigenetic patterns in both local joint tissues and the immune system that associate with osteoarthritis in human patients and animal models.

He has published numerous articles in peer-reviewed journals on the topic of epigenetics, OA, and autoimmune disease.  A native Oklahoman, he received his undergraduate biochemistry degree at the University of Oklahoma.  He went on to train in Internal medicine and Rheumatology and is dual-board certified in both disciplines; he holds faculty positions at both the University of Oklahoma Health Sciences Center and the Oklahoma Medical Research Foundation.  He is actively involved in scientific and clinical training of medical students, Internal Medicine residents, and Rheumatology Fellows.

He has received a number of awards for biomedical research, clinical and teaching excellence, and advocacy, including the Distinguished Fellow award from the American College of Rheumatology and the Junior Faculty Research Award from the American Federation for Medical Research. He has been funded grant support from a variety of private foundations and the National Institutes for Health.